New York, USA, Aug. 28, 2025 (GLOBE NEWSWIRE) -- Hodgkin’s Lymphoma Market Set to Reach New Heights by 2034 with Innovative Therapies and Clinical Successes | DelveInsight
The Hodgkin’s lymphoma market is witnessing steady growth driven by rising prevalence, improved diagnostic techniques, and increased awareness of hematologic malignancies. Advances in targeted therapies, such as antibody-drug conjugates and checkpoint inhibitors, are reshaping the treatment landscape and expanding therapeutic options. Favorable reimbursement policies and ongoing clinical trials are also contributing to market expansion.
DelveInsight’s Hodgkin's Lymphoma Market Insights report includes a comprehensive understanding of current treatment practices, emerging Hodgkin's lymphoma drugs, market share of individual therapies, and current and forecasted Hodgkin's lymphoma market size from 2020 to 2034, segmented into leading markets (the US, EU4, UK, and Japan).
Hodgkin's Lymphoma Market Summary
- According to DelveInsight’s analysis, the total Hodgkin's lymphoma treatment market size is expected to grow positively by 2034 in the leading markets (the US, EU4, UK, and Japan).
- The United States accounts for the largest market size of Hodgkin's lymphoma, in comparison to EU4 (Germany, Italy, France, and Spain) and the UK, and Japan.
- In 2024, an estimated 8,570 (4,630 in males and 3,940 in females) new cases of Hodgkin lymphoma are expected in the United States.
- Key Hodgkin’s lymphoma companies, including Merck, BeiGene, Tessa Therapeutics, Genmab, Bristol-Myers Squibb, AstraZeneca, and others, are actively working on innovative Hodgkin's lymphoma drugs.
- Some of the key Hodgkin's lymphoma therapies in clinical trials include Favezelimab/Pembrolizumab, TEVIMBRA (tislelizumab), Autologous CD30 CAR-T cells, GEN3017, Gemcitabine+ Bendamustine + Nivolumab, AZD3470, Ipilimumab ± Nivolumab, and others. These novel Hodgkin's lymphoma therapies are anticipated to enter the Hodgkin's lymphoma market in the forecast period and are expected to change the market.
Discover which Hodgkin's lymphoma medications are expected to grab the market share @ Hodgkin's Lymphoma Market Report
Key Factors Driving the Growth of the Hodgkin’s Lymphoma Market
Breakthroughs in immunotherapy (PD-1/PD-L1 inhibitors)
Checkpoint inhibitors (notably KEYTRUDA and OPDIVO) produced high response rates in relapsed/refractory classical Hodgkin lymphoma and have become standard options in many lines of therapy. Their strong clinical efficacy and expanding indications (including consolidation/earlier-line use in trials) are a major commercial growth engine.
Rising Hodgkin lymphoma prevalence
While Hodgkin lymphoma incidence is moderate, improved survival and durable remissions mean a growing prevalence, which raises demand for maintenance, salvage, and long-term therapies. Global hematologic cancer trends also show an increasing case burden in some regions.
Expanding indications and label extensions
Manufacturers are actively pursuing label expansions and combination regimens (e.g., ADC + chemotherapy, PD-1 + chemotherapy), as well as pediatric approvals in some markets. Each successful expansion increases the eligible patient population and adds new, reimbursable treatment options, a significant growth lever.
Robust Hodgkin’s lymphoma clinical pipeline
A growing pipeline, encompassing next-generation ADCs, combination CPI regimens, and anti-CD30 CAR-T cell programs, is generating multiple new commercial opportunities. Ongoing phase II trials (Autologous CD30 CAR-T cells) and encouraging early CAR-T data are attracting investment and creating near-term launch prospects that push market forecasts upward.
Hodgkin's Lymphoma Market Analysis
Current management of Hodgkin lymphoma typically combines chemotherapy, radiation therapy, and targeted therapies, with treatment strategies tailored to the stage and subtype of the disease. For advanced-stage cases, chemotherapy regimens such as ABVD (Adriamycin, Bleomycin, Vinblastine, and Dacarbazine) remain standard. In relapsed or refractory disease, targeted therapies like ADCETRIS and immune checkpoint inhibitors such as KEYTRUDA and OPDIVO play a central role.
KEYTRUDA is a humanized monoclonal antibody against PD-1 that enhances immune recognition of tumor cells by blocking PD-1 interactions with PD-L1 and PD-L2, thereby activating T lymphocytes. In October 2020, the FDA expanded its approval as monotherapy for adults with relapsed or refractory classical Hodgkin lymphoma under accelerated approval regulations, based on data from the KEYNOTE-087 trial. In this study of 210 patients, KEYTRUDA demonstrated an overall response rate (ORR) of 69%, including a 22% complete remission rate and a 47% partial remission rate.
Similarly, OPDIVO, another PD-1 blocking antibody, was granted accelerated approval by the FDA in May 2016 for relapsed or refractory classical Hodgkin lymphoma. OPDIVO received Breakthrough Therapy Designation, Orphan Drug status, and Priority Review, with its approval based on evidence of durable anti-tumor activity through the release of PD-1 pathway inhibition.
ADCETRIS is an antibody-drug conjugate that links an anti-CD30 monoclonal antibody to the cytotoxic agent monomethyl auristatin E (MMAE) via a cleavable linker, allowing selective delivery into CD30-positive tumor cells. Approved in more than 70 countries for relapsed or refractory Hodgkin lymphoma and systemic anaplastic large cell lymphoma (sALCL), ADCETRIS has expanded indications over time. In November 2022, the FDA approved its use in combination with multi-agent chemotherapy for pediatric patients (≥2 years) with previously untreated high-risk classical Hodgkin lymphoma—the first pediatric approval for brentuximab vedotin.
Learn more about the Hodgkin's lymphoma treatment options @ Hodgkin's Lymphoma Treatment Guidelines
Hodgkin's Lymphoma Competitive Landscape
The Hodgkin lymphoma has a strong pipeline, with many companies actively developing therapies. Key players include Merck (Favezelimab/pembrolizumab), Bristol Myers Squibb (Gemcitabine+ Bendamustine + Nivolumab; Ipilimumab ± Nivolumab), BeiGene (TEVIMBRA), AstraZeneca (AZD3470), Genmab (GEN3017), and others.
TEVIMBRA is a monoclonal antibody belonging to the class of drugs that target PD-1 or PD-L1, thereby blocking the PD-1/PD-L1 pathway. By lifting this immune checkpoint inhibition, it enhances immune activity but may also disrupt peripheral tolerance, leading to immune-related adverse effects.
In August 2024, BeiGene announced the completion of a Phase II trial of tislelizumab in patients with relapsed or refractory classical Hodgkin lymphoma (TIRHOL). Earlier, in March 2024, the company also reported on a Phase II trial evaluating tislelizumab as a first-line therapy for Hodgkin lymphoma in patients aged 60 and above, with study completion anticipated in 2028.
Favezelimab, an antibody targeting LAG-3 on tumor-infiltrating lymphocytes (TILs), blocks its interaction with MHC class II molecules on tumor cells. Merck is developing a combination of favezelimab and pembrolizumab for treating relapsed or refractory classical Hodgkin lymphoma and is currently conducting a Phase III trial.
Data from Phase I/II studies presented at ASCO 2024 showed an objective response rate (ORR) of 83% (n=25; 95% CI, 65–94), with complete responses in 11 patients (37%) and partial responses in 14 patients (47%). The median duration of response (DOR) was 17.0 months (range, 2.6–30.5), with 47% of responders maintaining responses at 24 months. Median progression-free survival (PFS) was 19.4 months (95% CI, 9.5–28.5), with a 24-month PFS rate of 46%. With longer follow-up, the favezelimab–pembrolizumab combination continued to demonstrate durable antitumor activity and a manageable safety profile in anti–PD-1–naive relapsed/refractory classical Hodgkin lymphoma.
The anticipated launch of these emerging Hodgkin's lymphoma therapies are poised to transform the Hodgkin's lymphoma market landscape in the coming years. As these cutting-edge Hodgkin's lymphoma therapies continue to mature and gain regulatory approval, they are expected to reshape the Hodgkin's lymphoma market landscape, offering new standards of care and unlocking opportunities for medical innovation and economic growth.
To know more about new treatment for Hodgkin's lymphoma, visit @ Hodgkin's Lymphoma Management
Recent Developments in the Hodgkin's Lymphoma Market
- In August 2024, BeinGene reported completion of the Phase II clinical trial of tislelizumab in participants with relapsed or refractory classical Hodgkin lymphoma (TIRHOL).
- In June 2024, Takeda and Pfizer announced that the German Hodgkin Study Group (GHSG) would present positive results from the Phase III HD21 trial of ADCETRIS (brentuximab vedotin) combined with chemotherapy in late-breaking oral presentations at the 60th American Society of Clinical Oncology (ASCO) Annual Meeting (LBA7000) and the 29th European Hematology Association (EHA) Annual Meeting.
Hodgkin's Lymphoma Overview
Hodgkin lymphoma is a type of cancer that originates in the lymphatic system and is distinguished by the presence of Reed-Sternberg cells. It is one of the two primary categories of lymphoma, the other being non-Hodgkin lymphoma. When detected and treated early, it is associated with a high cure rate. In this condition, B-lymphocytes grow uncontrollably and accumulate in areas such as the lymph nodes, impairing their ability to fight infections and making individuals more prone to illness. The disease is classified into two major forms: classic Hodgkin lymphoma and nodular lymphocyte-predominant Hodgkin lymphoma. Despite its aggressive nature and potential to spread rapidly, it remains one of the most treatable cancers.
Diagnosis of Hodgkin lymphoma generally begins with a biopsy of the affected tissue or lymph nodes. Immunophenotyping is then carried out to identify proteins expressed by the abnormal cells. Imaging techniques, including CT scans, X-rays, and PET scans of the chest, abdomen, and pelvis, are used to detect enlarged lymph nodes, spleen involvement, or other abnormalities. PET scans also help identify patients who may be treated effectively with chemotherapy alone, thereby reducing long-term risks linked to radiotherapy, such as heart disease or secondary cancers. Blood tests are performed to evaluate overall health, measure red and white blood cell counts, assess platelet levels, and monitor organ function, particularly of the liver and kidneys. Additionally, Fluorescence in Situ Hybridization (FISH) is used to analyze genetic and chromosomal changes in cells and tissues, aiding in the identification of specific abnormalities.
After diagnosis, the disease is staged to determine the extent of its spread. Staging ranges from stage I, where a single lymph node region or structure is involved, to stage IV, where the cancer has spread beyond the lymphatic system to other organs.
Hodgkin's Lymphoma Epidemiology Segmentation
The Hodgkin's lymphoma epidemiology section provides insights into the historical and current Hodgkin's lymphoma patient pool and forecasted trends for the leading markets (the US, EU4, UK, and Japan). It helps recognize the causes of current and forecasted patient trends by exploring numerous studies and views of key opinion leaders.
The Hodgkin's lymphoma market report proffers epidemiological analysis for the study period 2020–2034 in the leading markets (the US, EU4, UK, and Japan) segmented into:
- Total Incident Cases of Hodgkin Lymphoma
- Stage-specific incident cases of Hodgkin lymphoma
- Type-specific Incident cases of Hodgkin Lymphoma
- Age-specific Incident cases of Hodgkin Lymphoma
- Gender-specific Incident cases of Hodgkin Lymphoma
- Treatable cases of Hodgkin Lymphoma
Download the report to understand which factors are driving Hodgkin's lymphoma epidemiology trends @ Hodgkin's Lymphoma Treatment Algorithm
| Hodgkin's Lymphoma Market Report Metrics | Details |
| Study Period | 2020–2034 |
| Hodgkin's Lymphoma Market Report Coverage | 7MM [The United States, the EU-4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan] |
| Key Hodgkin's Lymphoma Companies | Merck, BeiGene, Tessa Therapeutics, Genmab, Bristol-Myers Squibb, AstraZeneca, Pfizer, Takeda, and others |
| Key Hodgkin's Lymphoma Therapies | Favezelimab/Pembrolizumab, TEVIMBRA (tislelizumab), Autologous CD30 CAR-T cells, GEN3017, Gemcitabine+ Bendamustine + Nivolumab, AZD3470, Ipilimumab ± Nivolumab, KEYTRUDA, OPDIVO, ADCETRIS, and others |
Scope of the Hodgkin's Lymphoma Market Report
- Hodgkin's Lymphoma Therapeutic Assessment: Hodgkin's Lymphoma current marketed and emerging therapies
- Hodgkin's Lymphoma Market Dynamics: Conjoint Analysis of Emerging Hodgkin's Lymphoma Drugs
- Competitive Intelligence Analysis: SWOT analysis and Market entry strategies
- Hodgkin's Lymphoma Market Unmet Needs, KOL’s views, Analyst’s views, Hodgkin's Lymphoma Market Access and Reimbursement
Discover more about Hodgkin's lymphoma drugs in development @ Hodgkin's Lymphoma Clinical Trials
Table of Contents
| 1 | Hodgkin's Lymphoma Market Key Insights |
| 2 | Hodgkin's Lymphoma Market Report Introduction |
| 3 | Executive Summary |
| 4 | Overview at a glance |
| 4.1 | Hodgkin's Lymphoma Market share distribution (%) by therapies in 2020 in the 7MM |
| 4.2 | Hodgkin's Lymphoma Market share distribution (%) by therapies in 2034 in the 7MM |
| 4.3 | Hodgkin's Lymphoma Market share distribution (%) by lines of therapies in 2020 in the7MM |
| 4.4 | Hodgkin's Lymphoma Market share distribution (%) by lines of therapies in 2034 in the 7MM |
| 5 | Key Events |
| 6 | Epidemiology and Hodgkin's Lymphoma Market Methodology |
| 7 | Disease Background and Overview |
| 7.1 | Introduction |
| 7.2 | Signs and Symptoms |
| 7.3 | Classification |
| 7.4 | Risk Factors |
| 7.5 | Diagnosis |
| 7.6 | Diagnostic Biomarkers |
| 7.7 | Differential Diagnosis |
| 7.8 | Staging |
| 8 | Treatment of Hodgkin Lymphoma |
| 8.1 | Hodgkin's Lymphoma Treatment Algorithm |
| 8.2 | Hodgkin's Lymphoma Treatment Guidelines |
| 9 | Hodgkin's Lymphoma Epidemiology and Patient Population |
| 9.1 | Key Findings |
| 9.2 | Assumptions and Rationale |
| 9.3 | Total Incident Cases of Hodgkin Lymphoma in the 7MM |
| 9.4 | The United States |
| 9.4.1 | Total Incident cases of Hodgkin Lymphoma in the US |
| 9.4.2 | Stage-specific Incident cases of Hodgkin Lymphoma in the US |
| 9.4.3 | Type-specific Incident cases of Hodgkin Lymphoma in the US |
| 9.4.4 | Age-specific Incident cases of Hodgkin Lymphoma in the US |
| 9.4.5 | Gender-specific Incident cases of Hodgkin Lymphoma in the US |
| 9.4.6 | Treatable cases of Hodgkin Lymphoma in the US |
| 9.5 | EU4 and the UK |
| 9.6 | Japan |
| 10 | Hodgkin's Lymphoma Patient Journey |
| 11 | Hodgkin's Lymphoma Marketed Drugs |
| 11.1 | Key Competitors |
| 11.2 | KEYTRUDA (pembrolizumab): Merck |
| 11.2.1 | Product Description |
| 11.2.2 | Regulatory Milestones |
| 11.2.3 | Other Developmental Activities |
| 11.2.4 | Current Pipeline Activity |
| 11.2.4.1 | Clinical Trials Information |
| 11.2.5 | Safety and Efficacy |
| 11.3 | OPDIVO (nivolumab): Bristol Myers Squibb |
| 11.4 | ADCETRIS: Takeda/Pfizer |
| 12 | Hodgkin's Lymphoma Emerging Drugs |
| 12.1 | Key Competitors |
| 12.2 | Favezelimab/pembrolizumab: Merck |
| 12.2.1 | Product Description |
| 12.2.2 | Other Developmental Activities |
| 12.2.3 | Clinical Development |
| 12.2.3.1 | Clinical Trial Information |
| 12.2.4 | Safety and Efficacy |
| 12.2.5 | Analyst Views |
| 12.3 | TEVIMBRA (tislelizumab): BeiGene |
| List to be continued in report……. | |
| 13 | Hodgkin Lymphoma Market: The 7MM Analysis |
| 13.1 | Key Findings |
| 13.2 | Hodgkin's Lymphoma Market Outlook |
| 13.3 | Conjoint Analysis |
| 13.1 | Key Hodgkin's Lymphoma Market Forecast Assumptions |
| 13.2 | Total Market Size of Hodgkin Lymphoma in the 7MM |
| 13.3 | United States Market Size |
| 13.3.1 | Total Market Size of Hodgkin Lymphoma in the United States |
| 13.3.2 | Market Size Of Hodgkin Lymphoma by Therapies in the United States |
| 13.4 | EU4 and the UK Market Size |
| 13.5 | Japan Market Size |
| 14 | Hodgkin's Lymphoma Market Unmet Needs |
| 15 | Hodgkin's Lymphoma Market SWOT Analysis |
| 16 | KOL Views |
| 17 | Hodgkin's Lymphoma Market Access and Reimbursement |
| 17.1 | United States |
| 17.2 | EU4 and the UK |
| 17.3 | Japan |
| 18 | Bibliography |
| 19 | Hodgkin's Lymphoma Market Report Methodology |
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Hodgkin's Lymphoma Clinical Trial Analysis
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